Calendar – Københavns Universitet

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  • 23. november 2018, kl. 13:00-17:00

    PhD Defense by Diana Vladimirova

    Title: "High-resolution methane record of the RECAP ice core (Eastern Greenland) over the last climatic cycle" » Læs mere

  • 23. november 2018, kl. 13:30

    Master thesis defense by Ditte Karina Nielsen

    NMR as Tools for Studying Chelation of Copper and Other Metal Ions into DOTA and DOTA-functionalized Molecules The chelation of copper(II) to DOTA - 1,4,7,10 – tetraazacyclododecane – 1,4,7,10 – tetraacetic acid has by the influence of solvent-concentrations, pH and temperature been found to provide useful insights into the properties of the chelator-system. The chelation of copper(II) to the DOTA-molecule can be measured by the use of NMR-methods where the kinetics and stability of the molecule can be examined in order to understand the de- and trans- chelating pathways. When radionuclides are used in radiotherapy for MRI- and PET-scans the techniques are based upon NMR methods that have their origins in the classical and quantum mechanical physics. 13 NMR measurements were therefore performed including two 2D spectra in order to analyze the de- and trans-chelating pathways of the copper metal-ion based upon the theories that governs NMR. Under the assumption that concentration, pH and temperature plays a larger part in the binding of the metal-ion to the DOTA-molecule these three parameters have been varied aiming to increase the copper-concentration in the solution in an interest to gain knowledge of the stability and the binding-properties of copper to the chelator. The effect of the paramagnetic Cu2+ metal-ion in aqueous solutions have from theory emphasized the experimental part by the increased concentration of copper in order to promote the binding of the metal-ion to the DOTA-molecule. All three parameters were varied with the temperature kept within the range of 24.2o – 28o C. and the pH in the solution, H2O and D2O in a ratio of 1:9 were kept at a range between, pH = 7. 38 to 7.43 with added buffer of copperacetate at a pH = 3.87. The copper-concentration was gradually increased in volumes of 10 𝜇L in the 1D NMR measurements. This gave an undifferentiated result in the analysis of the NMR spectras that showed no results of binding between copper and DOTA but only indications of the presence and chelation of the copper-ion to the DOTA-molecule by increased concentrations of copper. It was then hypothetially proposed from the literature and theory that the chelation is dependent on the coordination of the watermolecules in concert with the DOTA-molecule. The increase of the copper-concentration in a max. increase in volume of 20 𝜇L is although ideal when forming the complex into a stable chelation with the DOTA-molecule but is dependent on the coordinated effort in an orchestrated manner upon the water-molecules given the structural and geometrical pre-requisistes of the copper and the DOTA- molecules. » Læs mere

  • 23. november 2018, kl. 15:00

    Nano-Science Seminar: Peter Bøggild

    We invite you to join us at Nano-Science Seminar, held by Professor Peter Bøggild, November 23rd 15:00 in Aud 6 at HCØ. Bøggild's group, NANOCARBON, focuses almost entirely on graphene and other 2D materials, and the manufacturing and applications hereof. 

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  • 23. november 2018, kl. 09:30

    Quantum Optics Seminar by Ewold Verhagen

    Direct observation of topologically protected edge states in silicon photonic crystals: Propagation, dispersion, and chirality
    Ewold Verhagen, AMOLF Amsterdam

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